Featured speakers


Adrian R. Ferré-D.Amaré
NIH, Bethesda, USA
RNA mimics of GFP and RFP: new tools for the in vivo study of noncoding RNAs
John L. Woolford Jr.
Carnegie Mellon University, Pittsburgh, USA
Remodeling events driving ribosome assembly in Saccharomyces cerevisiae
Alexander Mankin
University of Illinois at Chicago, Chicago, USA
Ribo-T, the ribosome with covalently linked subunits
Elissa Lei
NIH, Bethesda, USA
Argonaute2 functions with LaminB to Mediate Transcriptional Silencing of Spermatogenesis Genes
Beate Schwer
Weill Cornell Medical College, New York, USA
The role of RNA polymerase II CTD phospho-sites in the repression of pho1 gene expression by lncRNA transcription
David Bentley
University of Colorado, Denver, USA
Spatial and kinetic coupling of co-transcriptional processes in mRNA synthesis
David Engelke
University of Colorado, Denver, USA
Aggregation and amyloid fiber formation by Mod5 is affected by RNA binding
Andrey S. Krasilnikov
Penn State University, University Park, USA
Proteins in catalytic RNPs: from RNase P to telomerase
Gisela Storz
NIH, Bethesda, USA
Not just ncRNAs: overlap between protein coding and regulation
Jingyi Fei
The University of Chicago, Chicago, USA
Determination of in vivo regulation kinetics of small non-coding RNA in bacteria
Éric Massé
Université de Sherbrooke, Sherbrooke, Canada
The RNA chaperone Hfq directly binds target mRNAs to promote sRNA-mediated cleavage
Ben Luisi
University of Cambridge, Cambridge, UK
The dynamic machinery of RNA degradation, processing and riboregulation in E. coli
Sean A. McKenna
University of Manitoba, Winnipeg, Canada
Recognition of unique RNA structures by quadruplex helicases and their functional consequences
Jean-Pierre Perreault
Université de Sherbrooke, Sherbrooke, Canada
The G-Quadruplex Translation Regulation of BAG-1; an mRNA Involved in Colorectal Cancer
Jean-Louis Mergny
Université de Bordeaux, Bordeaux, France
Quadruplexes are everywhere!
Jonathan D. Dinman
University of Maryland, College Park, USA
A programmed ribosomal frameshifting defect potentiates the transforming activity of the JAK2-V617F mutation
Jean Schaffer
Washington University School of Medicine, St. Louis, USA
Rpl13a snoRNAs are critical mediators of metabolic stress
Michelle Scott
Université de Sherbrooke, Sherbrooke, Canada
Small nucleolar RNAs as regulators of gene expression
Denis L.J. Lafontaine
Université Libre de Bruxelles, Charleroi, Belgium
The human box C/D snoRNAs U3 and U8 are required for pre-rRNA processing and tumorigenesis
Stephen Rader
University of Northern British Columbia, Prince George, Canada
A single LSm complex in C. merolae associated with splicing factors
Tony Russell
University of Lethbridge, Lethbridge, Canada
Characterization of snRNAs, snoRNAs and other ncRNAs, and their protein binding partners in model protists
Andrea Barta
University of Vienna, Vienna, Austria
The fate of alternative spliced transcripts in plants
Arthur Günzl
UConn Health, Farmington, USA
Deciphering the spliced leader trans splicing machinery in trypanosomes
Brenton Graveley
University of Connecticut Health Center, Farmington, USA
Comprehensive Characterization of the Functional RNA Elements Encoded in the Human Genome
Daniel Larson
NIH, Bethesda, USA
Regulation of Transcription and Splicing in Single Cells: Understanding Heterogeneity in Gene Expression


Adrian Krainer
The old Spring Harbor Laboratory, New York, USA
Mechanism-based antisense therapy targeting splicing or NMD
Eric Westhof
Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France
Non-Watson-Crick base pairs, RNA architectural modules and recognition fidelity in translation
Witold Filipowicz
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Mechanism and Regulation of miRNA-mediated Repression in Cultured Cells and Mouse Retina
Martine Simonelig
Institute of Human Genetics, Montpellier, France
Messenger RNA regulation by the piRNA pathway in drosophila
Bertrand Seraphin
IGBMC, Illkirch, France
Starting from the end: From eukaryotic mRNA decay mechanisms to diseases
Bryan R. Cullen
Duke University, Durham, USA
Viruses and microRNAs
Robert Feil
IGMM, Montpellier, France
Role of non-coding RNAs in mammalian genomic imprinting
Michael Kiebler
LMU, Munich, Germany
The role of RNA-binding proteins in dendritic mRNA localization
Edouard Bertrand
IGMM, Montpellier, France
Systematic analysis of the sub-cellular localization of mRNAs coding for motor proteins
Howard Lipshitz
University of Toronto, Toronto, Canada
Spatial and temporal control of the maternal-to-zygotic transition in Drosophila
Nahum Sonenberg
McGill University, Montreal, Canada
Translational control by the eIF4E homolog, 4EHP
Jeffrey Kieft
University of Colorado, Aurora, USA
Structure and function of viral RNAs that manipulate or co-opt host cell machinery
Rachel Green
Howard Hughes Medical Institute, Baltimore, USA
Messenger RNA surveillance revealed by biochemistry and ribosome profiling
Nicholas Ingolia
University of California, Berkeley, USA
Rocaglamide A converts RNA helicase eIF4A into a sequence-specific translational repressor
Alain Jacquier
Institut Pasteur, Paris, France
Quality control of transcription start site selection by nonsense-mediated-mRNA decay
Gene Yeo
UC San Diego, La Jolla, USA
Large-scale discovery of RNA binding sites and assigning of functions to RNA binding proteins
Jeffrey Pleiss
Cornell University, New York, USA
Widespread alternative and aberrant splicing revealed by lariat sequencing
Mathieu Quesnel-Vallières
University of Toronto, Toronto, Canada
Role of a neuronal-specific alternative splicing regulatory network in autism spectrum disorders
Benoit Chabot
Université de Sherbrooke, Sherbrooke, Canada
Connecting DNA damage to the alternative splicing of apoptotic and DNA repair genes
Karla Neugebauer
Yale School of Medicine, New Haven, USA
Co-transcriptional splicing: full speed ahead!
Jamal Tazi
IGMM, Montpellier, France
Durable control of viral rebound with a new drug ABX464 targeting Rev . mediated viral RNA biogenesis
Thomas Cooper
Baylor College of Medicine, Houston, USA
Alternative splicing regulatory networks in development and their disruption in disease
Mariano Garcia Blanco
University of Texas Medical Branch, Galveston, USA
The RNA helicase DDX39B regulates alternative splicing of the interleukin-7 receptor exon 6 and is a novel susceptibility gene for Multiple Sclerosis
Wenqian Hu
Mayo Clinic, Minnesota, USA
Regulation of erythropoiesis by mRNA-binding proteins
Utz Fischer
University of Würzburg, Würzburg, Germany
Mechanistic dissection of UsnRNP biogenesis and its role in disease
Charles Thornton
University of Rochester, Rochester, USA
RNA-targeted treatment for myotonic dystrophy
Paul McKellips
One Health Research, Washington D.C., USA
The Miracle


Alan Lambowitz
The University of Texas, Austin, USA
Mobile Group II Introns: Mechanisms, Evolution, and Biotechnological Applications
Christina Smolke
Stanford University, Stanford, USA
Designing synthetic regulatory RNAs: new tools for temporal and spatial control in biological systems
Ron Breaker
Yale University, New Haven, USA
Prospects for Ribozyme Discovery and Analysis
Eduardo Groisman
Yale University, New Haven, USA
Gene control by bacterial mRNA leaders
Haifan Lin
Yale University, New Haven, USA
Retrotransposons and pseudogenes regulate mRNAs and lincRNAs via the piRNA pathway in the germline
Matt Simon
Yale University, New Haven, USA
Insight into lncRNA function and mechanism using capture hybridization analysis
Philip C. Bevilacqua
Penn State University, State College, USA
Combining experiments with theory to obtain deeper insight into ribozyme mechanism
Peter Baumann
Stowers Institute, Kansas City, USA
Telomerase biogenesis, stability and regulation in fission yeasts and other fungi
Julian Chen
Arizona State University, Phoenix, USA
Divergent structure and mechanism of telomerase ribonucleoprotein
Susan Baserga
Yale University, New Haven, USA
RNA polymerase I transcription and craniofacial dysmorphology
Maria Barna
Stanford School of Medicine, Stanford, USA
Specialized Ribosomes: A new frontier in gene regulation, organismal development and evolution
Antonio Giraldez
Yale University, New Haven, USA
Gene regulation during embryonic development from microRNAs to micropeptides
Wendy Gilbert
MIT, Cambridge, USA
Pseudouridine profiling (Pseudo-seq) reveals widespread regulated mRNA pseudouridylation in yeast and human cells
Joan Steitz
Yale University, New Haven, USA
Structural Insights into the Stabilization of MALAT1 Noncoding RNA by Formation of a Bipartite Triple Helix
Jens Lykke-Andersen
UC San Diego, San Diego, USA
Target discrimination in the nonsense-mediated decay pathway is governed by the differential ability of mRNPs to promote ATPase-powered UPF1 release
Ian Eperon
University of Leicester, Leicester, UK
RNA splicing: still in Plato's cave?
Hervé Le Hir
IBENS, Paris, France
The versatility of RNA helicases highlighted by the Exon Junction Complex
Sandra Wolin
Yale University, New Haven, USA
A new class of bacterial noncoding RNAs that are tRNA mimics
Javier Martinez
Institute of Molecular Biotechnology, Vienna, Austria
The human tRNA ligase complex and Archease: A dual enzyme with functions beyond tRNA splicing
John Rinn
Harvard University and Medical School, Cambridge, USA
RNA binding proteins interact specifically with transposable element sequence in human genes
Nikolaus Rajewsky
Max Delbrück Center for Molecular Medicine, Berlin, Germany
Regulatory RNAs
Shu-ou Shan
California Institute of Technology, Pasadena, USA
Molecular Mechanism of an Essential Targeting Machine
Brian Nosek
University of Virginia, Charlottesville, USA
Scientific Utopia: Improving Openness and Reproducibility in Scientific Research


John Mattick
University of Queensland, Brisbane, Australia
The hidden layer of regulatory RNA in human development
Harry Noller
University of California, Santa Cruz, USA
Structural Changes in the Ribosome During Translocation
Christian Spahn
Humboldt Universität, Berlin, Germany
Structure and structural dynamics of mammalian ribosomal complexes during translation elongation
Kurt Fredrick
The Ohio State University, Columbia, USA
Learning from ribosomes that make mistakes
Feng Zhang
Broad Institute of MIT, Boston, USA
Genome Engineering: Technologies and Applications
Hiroaki Suga
University of Tokyo, Tokyo, Japan
Genetic code reprogramming for the expression of de novo macrocycles
Matthew Levy
Albert Einstein College of Medicine, New York, USA
Aptamer-targeted antigen delivery
Danesh Moazed
Harvard Medical School, Boston, USA
RNAi-mediated heterochromatin formation
Alan Bernstein
Canadian Institute for Advanced Research, Toronto, Canada
My life as an RNA molecule
Roy Parker
University of Colorado, Boulder, USA
The eukaryotic mRNA cycle: Movement of yeast mRNAs between polysomes, stress granules, and P-bodies and its role in the control of translation and degradation
Toshifumi Inada
Tohoku University, Sendai, Japan
Novel E3 ubiquitin ligase is required for an endonucleolytic cleavage of mRNA by translation arrest
Fabrizio d.Adda di Fagagna
IFOM Foundation, Milan, Italy
The direct role of nuclear non coding RNAs at sites of DNA damage in the control of genome integrity
André Verdel
Université Joseph Fourier, Grenoble, France
RNA-mediated epigenetic silencing in fission yeast
Shinichi Nakagawa
RIKEN, Hirosawa, Japan
Functional analyses of abundant nuclear long noncoding RNAs
Piero Carninci
RIKEN Center for Life Science Technologies, Kobe, Japan
The complexity of mammalian transcription
Doug Black
UCLA, Los Angeles, USA
Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid-A induced gene expression
Stefan Stamm
University of Kentucky, Lexington, USA
Regulation of gene expression by processed snoRNAs
Tsutomu Suzuki
University of Tokyo, Tokyo, Japan
RNA modifications as naturally-selected chemical diversity involved in various biological processes
Mikiko Siomi
University of Tokyo, Tokyo, Japan
Biogenesis of PIWI-interacting RNAs


Larry Gold
Somalogic Inc., University of Colorado, USA
Human Proteomics at Scale: SOMAmers and the SOMAscan Platform
Wade C. Winkler
University of Maryland College Park, USA
Regulatory RNAs in Bacillus subtilis
Victor Ambros
University of Massachusetts Medical School, Worcester, USA
MicroRNA pathways link development and stress responses in C. elegans
Bill Theurkauf
University of Massachusetts Medical School, Worcester, USA
Organization of a transposon silencing compartment
Andrei Korostelev
University of Massachusetts Medical School, Worcester, USA
Mechanistic insights into translation termination
Georgios Skiniotis
University of Michigan, Ann Arbor, USA
Molecular Architecture of a Late 40S Ribosome Assembly Intermediate
Jeanne Lawrence
University of Massachusetts Medical School, Worcester, USA
XIST RNA in Chromosome Regulation and Architecture: Implications for the Repeat Genome
Craig Mello
University of Massachusetts Medical School, Worcester, USA
Surveillance of transcription and persistent silencing of foreign sequences in the C. elegans germline
Maurice Swanson
University of Florida, Gainesville, USA
The Expanding Universe of RNA-Mediated Disease
Ellen Welch
PTC Therapeutics Inc., South Plainfield, USA
Identifying small molecules for the treatment of orphan diseases
Matt Disney
The Scripps Research Institute, Jupiter, USA
Rational Design of Small Molecules Targeting RNA from Sequence
Gary Bassell
Emory University, Atlanta, USA
Regulation of local mRNA translation by the fragile x mental retardation protein and microRNAs
James Manley
Columbia University, New-York, USA
Processing of mRNA precursors and links to human disease
Eric Lai
Memorial Sloan-Kettering, New-York, USA
Biogenesis and function of microRNAs
Allan Jacobson
University of Massachusetts Medical School, Worcester, USA
NMD and the dynamic interactions of yeast Upf factors
Mike Kiledjian
Rutgers University, Piscataway, USA
mRNA 5´-end Quality Control
Jeff Coller
Case Western Reserve University, Cleveland, USA
Decapping of coding and non-coding RNAs
Melissa Moore
University of Massachusetts Medical School, Worcester, USA
Nuclear RNP Egress by Nuclear Envelope Budding
Kristen Lynch
University of Pennsylvania, Philadelphia, USA
Regulation of splicing through extended spliceosomal contacts
Joseph Gall
Carnegie Institute of Science, USA
Revisiting Lampbrush Chromosomes


Gary Ruvkun
Massachusetts General Hospital, Boston, MA
Small RNAs of C. elegans
Jennifer Doudna
University of California, Berkeley, USA
Dicing and Beyond: Regulatory RNA in Humans and Bacteria
James E. Dahlberg
University of Wisconsin - Madison, USA
Limiting Ago proteins restricts RNAi during X. laevis early development
Paul Fox
Cleveland Clinic Lerner College of Medicine, USA
The GAIT system and the "translational trickle" control mechanism
Martin Dutertre
Centre Léon Bérard, Lyon, France
Alteration of the coupling between transcription and splicing hits the core of the genotoxic stress response
David Wassarman
University of Wisconsin Madison, USA
Control of alternative splicing by signal-dependent degradation of splicing regulatory proteins
Andrew White
York University, Canada
Regulation of RNA virus processes by long-range RNA-RNA interactions
Biao Ding
Ohio State University, USA
RNA motif-mediated intercellular RNA trafficking
Andrés Aguilera
CABIMER, Sevilla, Spain
Factors and mechanisms connecting mRNP biogenesis and genome instability
David Zappulla
Johns Hopkins University, Baltimore, USA
Telomerase RNP mechanism in yeast: determining the limits of flexibility within the 1157-nt RNA
Frédéric Allain
Institute of Molecular Biology and Biophysics, Zürich, Switzerland
Guanine recognitions by Lin28 zinc-binding domains and SR protein RRMs
Robert Batey
University of Colorado at Boulder, USA
Structural and Mechanistic Studies of Riboswitches
Domenico Libri
Centre de Génétique Moléculaire, Paris, France
A comprehensive analysis of exosome targets in yeast S. cerevisiae
Françoise Stutz
Université de Genève, Switzerland
Characterization of antisense mediated transcriptional gene silencing
Jody Puglisi
Stanford University School of Medicine, USA
Dynamics of Translation Initiation
David Rueda
Wayne State University, Detroit, USA
RNA Folding Memory Effects
Robert Singer
Albert Einstein College of Medicine of Yeshiva University, Bronx, USA
Single molecule mRNA decay measurements reveal promoter regulated mRNA stability in yeast
David Grünwald
Delft University of Technology, The Netherlands
Crossing The Gate: Imaging mRNAs with Millisecond Time Resolution Inside Living Cells
Peter Moore
Yale University, USA
How We Got Here: an Informal History of the Structural Biology of RNA


Marvin Wickens
University of Wisconsin, Madisson, USA
Proteins that control mRNAs: from finding a partner to making a memory
Jörg Vogel
University of Wurzburg, Germany
Bacterial small RNAs have come a long way
Paul Myers
University og Minnesota, Morris, USA
Communicating science to a fickle public


Jack Szostack
Harvard Medical School, Massachusetts General Hospital, Boston, MA
The Origin of Life and the Emergence of Darwinian Evolution
Phillip Sharp
Massachusetts Institute of Technology, Cambridge , MA
Ribonicleotides in Life
Timothy W. Nilsen
Case Western Center for RNA Molecular Biology, Clevland, OH
Overview of the current state of RNA Molecular Biology
W. Ford Doolittle
Dalhousie University, Halifax, NS
Why are molecular machines such as the editosome, the spliceosome and the ribosome so ridiculously complex?
Sandra Wolin
Yale University School of Medicine, New Haven, CT
One ring to find them: A bacterial Ro protein adapts an exoribonuclease for stress-induced RNA decay
Roy Parker
University of Arizona, Tucson, AZ
The Eukaryotic mRNA Cycle: Movement of yeast mRNAs between polysomes, stress granules, and P-bodies and its role in the control of translation and degradation
David Tollervey
Wellcome Trust Centre for Cell Biology and Centre for System Biology, University of Edinburgh, Edinburgh, UK
Same Cracking Results with RNA
Gideon Dreyfuss
University of Pennsylvania School of Medecine, Philadelphia, Pennsylvania
Ribonucleoproteins in mRNA processing and disease
Paul Griffiths
University of Sydney, Sydney, Australia
The Evolving Concept of Homology
Robert Darnell
The Rockefeller University, New York, NY
Decoding protein-RNA regulation with HITS-CLIP maps
Mariano Garcia-Blanco
Duke University, Durham, North Carolina
Imaging splicing reveals phenotypic transitions in cancer cells
Tom Maniatis
Harvard University, Cambridge, MA
A Possible Role of RNA Metabolism in ALS Disease Mechanisms
Alan Hinnebusch
Laboratory of Gene Regulation and Development, Bethesda, MD
Structural elements in elF1A regulate AUG selection by controlling distinct modes of initiator binding tot he preinitiation complex
Thomas Steitz
Yale University, New Haven, CT
Understanding function from structures of elongation factors, tRNAs and antibiotics bound to the 70S ribosome
Nahum Sonenberg
McGill University, Montreal, Quebec, Canada
Translational Control of Cell Proliferation by the 4E-Binding Proteins
Victor Ambros
University of Massachusetts Medical School, Worcester, MA
MicroRNA Pathways in animal development
Joan Steitz
Yale University, New Haven, CT
Regulating the activity of MicroRNAs in vertebrate cells
Lynne Maquat
University of Rochester, Rochester, NY
Regulation of gene expression through quality-control and condition-dependant mechanisms of mRNA decay
Shiv Grewal
Natinal Cancer Institute, Bethesda, Maryland
RNAi-mediated Epigenetic control of the genome
Robin Allshire
The University of Edinburgh, Scotland, UK
Synthetic heterochromatin can bypass RNAi to from heterochromatin and functional centromeres
Jef Boeke
Johns Hopins University, Baltimore, MD
Building Saccharomyces cerevisiae v2.0: The Synthetic Yeast genome project
Ronald Breaker
Yale University, New Haven, CT
Large Noncoding RNAs in bacteria
Alan Lambowitz
University of Texas at Austin, Austin, TX
Mobile group II introns: site-specific integration into DNA and application in gene targeting
Allan Jacobson
University of Massachusetts Medical School, Worcestor, MA
Genetic nonsense: from bench to beside
Muthiah Manoharan
Alnylam Pharmaceticals, MassachusettsUniversity of Texas at Austin, Austin, TX
Making siRNA into drugs using chemistry
Peter Campochiaro
Johns Hopkins University,School of Medecine, Baltimore, MD
Toll-like receptor 3 is falsely accused
Alexander Rich
Massachusetts Institute of Technology, Cambridge, MA
Teh ERA of RNA awakening: structural biology of RNA in the Early Years


Reinhard Lührmann
Max Planck Institute for Biophysical Chemistry, Göttingen, Germany
At the heart of the splicesome
Susan Gottesman
National Cancer Institute, NIH, Bethesda, MD, USA
Network of small RNAs and their regulators E.coli
Karla M. Neugebauer
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
What is necessary for gender equality in science?


Gideon Dreyfuss
University of Pennsylvania School of Medicine, Philadelphia, USA
The SMN complex: a molecular assembly machine for RNPs
Jack Szostak
Harvard Medical School, Boston, USA
Towards the design and synthesis of a simple artificial cell
Boyan Konforti
Nature Structural & Molecular Biology
The editorial process and the habits of effective authors


Robert Darnell
The Rockfeller University, New York, USA
Modular regulation of RNA in the brain
Jef Boeke
The Johns Hopkins University School of Medicine, Baltimore, USA
Retrotransposons - gene mobilization through an RNA intermediate
Dorit Zuk
Molecular Cell,
Life as Scientific Editor


Alan Weiner
University of Washington, Seattle, USA
CCA-adding enzymes: Sequence-specific RNA polymerases with no nucleic acid template
Ronald Breaker
Yale University, New Haven, USA
Genetic control by riboswitches and ribozymes


David Bartel
Whitehead Institute for Biomedical Research, Cambridge, USA
Small Regulatory RNAs in animals and plants
Kazunari Taira
University of Tokyo, Japan
RNA-based rapid identification of functional genes


Sandra Wolin
Yale University, New Heaven, USA
RNA folding and misfolding within cells: lessons from patients with autoimmune disease
Brenda Bass
University of UTAH, Salt Lake City, USA
dsRNA binding proteins in RNA editing and RNAi


Joachim Frank
Wadsworth Center, New York, USA
The dynamics of ribosome-ligand interaction as explored by cryo-EM
Lynne Maquat
University of Rochester, Rochester, USA
Nonsense-mediated mRNA decay in mammalian cells: Evidence for a pioneer round of translation


Phillip Sharp
Massachusetts Institute of Technology, Cambridge, USA
Iain Mattaj
European Molecular Biology Laboratory, Germany


Sidney Altman
Yale University, New Heaven, USA
Nahum Sonenberg
McGill University, Montréal, Canada